|
KMID : 0043320080310020242
|
|
Archives of Pharmacal Research
2008 Volume.31 No. 2 p.242 ~ p.249
|
|
|
Evaluation of Skin Permeation and Accumulation Profiles of a Highly Lipophilic Fatty Ester
|
|
Bhandari Krishna Hari
Lee Dong-Xun
Newa Madhuri
Yoon Sung-Il
Kim Jung-Sun
Yoo Bong-Kyo
Kim Jung-Ae
Kim Dae-Duk
Woo Jong-Soo
Lyoo Won-Seok
Lee Jae-Hwi
Choi Han-Gon
Yong Chul-Soon
|
|
|
Abstract
|
|
|
|
The aim was to evaluate the skin permeation and accumulation profiles of a highly lipophilic fatty ester using the combination of various permeation enhancing techniques to study the potential of highly lipophilic fatty esters as local topical agents. Permeation and accumulation profiles of ketorolac stearate (C18:0) were studied using solubility improved formulation, supersaturated solution of permeant in enhancer vehicle, lipophilic receptor solution, enhancer pretreatment, and the removal of stratum corneum and delipidization of skins. Impermeability and minimal skin accumulation of ketorolac stearate could delineate a preliminary possibility for designing safer topical agents without systemic absorption.
|
|
|
KEYWORD
|
|
|
Fatty esters, Ketorolac stearate, Skin permeation, Skin accumulation, Local topical agent
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|